An In Silico Study of Electrophysiological Parameters That Affect the Spiral-Wave Frequency in Mathematical Models for Cardiac Tissue

Spiral waves of excitation in cardiac tissue are associated with life-threatening arrhythmias. It is, therefore, important to study the electrophysiological factors that affect dynamics these spiral waves. By using an electrophysiologically detailed mathematical model a myocyte (cardiac cell), we effects cellular parameters, such as membrane-ion-channel conductances, on properties action-potential (AP) myocyte. We then investigate how changes properties, specifically upstroke velocity and AP duration (APD), frequency ω wave use for human-ventricular tissue. find increase (decrease) this upstroke-velocity or decrease (increase) increases (decreases) . also other intercellular factors, fibroblast-myocyte coupling, diffusive coupling strength, effective number neighboring myocytes fibroblasts, modulate Finally, demonstrate can drift region high density fibroblasts. Our results provide natural explanation anchoring highly fibrotic regions hearts.